Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10683082 | 0.84 | KMT2A (0.71) | POLBGAAMEN1KMT2AMAPT | |
| SCHEMBL9513736 | 0.83 | POLB (0.49) | POLBGAATDP1MEN1KMT2A | |
| SCHEMBL9517111 | 0.82 | HRH3 (0.49) | POLBGAATDP1MEN1KMT2A | |
| SCHEMBL7404283 | 0.81 | POLB (0.55) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9513582 | 0.81 | POLB (0.52) | POLBGAATDP1MEN1KMT2A | |
| SCHEMBL8891426 | 0.81 | HRH3 (0.57) | POLBGAAMEN1KMT2AMAPT | |
| SCHEMBL27463569 | 0.80 | POLB (0.64) | POLBMAPTALDH1A1KDM4EHTR1A | |
| SCHEMBL9658762 | 0.80 | ALDH1A1 (0.55) | POLBGAATDP1MEN1KMT2A | |
| SCHEMBL7404280 | 0.80 | POLB (0.51) | POLBGAATDP1MEN1KMT2A | |
| SCHEMBL10712134 | 0.79 | ALDH1A1 (0.56) | POLBTDP1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |