Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512301 | 0.77 | TDP1 (0.51) | HMGCRNR3C1 | |
| SCHEMBL7054339 | 0.73 | TDP1 (0.52) | — | |
| SCHEMBL13768714 | 0.70 | HMGCR (0.43) | HMGCR | |
| SCHEMBL10041024 | 0.70 | HMGCR (0.43) | HMGCR | |
| SCHEMBL9267781 | 0.69 | LMNA (0.55) | — | |
| SCHEMBL6282511 | 0.69 | LMNA (0.55) | — | |
| SCHEMBL5746058 | 0.69 | NPC1 (0.50) | — | |
| SCHEMBL9662241 | 0.68 | CREBBP (0.36) | — | |
| SCHEMBL13260909 | 0.67 | HMGCR (0.41) | HMGCR | |
| SCHEMBL9274167 | 0.67 | TOP2A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341681-B1 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AG (DE) | 1993-12-29 | — | — | EP | claimed |
| US-5166171-A | Compounds for treatment of artheriosclerosis and hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | claimed |
| EP-0341681-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-15 | — | — | EP | claimed |
| JP-1319472-A | — | — | None | — | — | JP | disclosed |
| EP-0341681-B1 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| US-5166171-A | Compounds for treatment of artheriosclerosis and hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| JP-H01319472-A | 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONE AND 6-THIOPHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONE AND THEIR DERIVATIVES | HOECHST AG | 1989-12-25 | — | — | JP | disclosed |
| EP-0341681-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-15 | — | — | EP | disclosed |