Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HMGCR | P04035 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20617560 | 0.84 | TDP1 (0.61) | TDP1GRM2MAPK1L3MBTL1 | |
| SCHEMBL6282511 | 0.79 | LMNA (0.55) | — | |
| SCHEMBL9267781 | 0.79 | LMNA (0.55) | — | |
| SCHEMBL5746058 | 0.78 | NPC1 (0.50) | — | |
| SCHEMBL9514007 | 0.77 | HMGCR (0.41) | NR3C1HMGCR | |
| SCHEMBL3622914 | 0.76 | TDP1 (0.56) | TDP1GRM2MAPK1L3MBTL1 | |
| SCHEMBL9629992 | 0.74 | TDP1 (0.57) | TDP1GRM2MAPK1L3MBTL1 | |
| SCHEMBL7757693 | 0.74 | — | — | |
| SCHEMBL10041024 | 0.74 | HMGCR (0.43) | HMGCR | |
| SCHEMBL13768714 | 0.74 | HMGCR (0.43) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341681-B1 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AG (DE) | 1993-12-29 | — | — | EP | claimed |
| US-5166171-A | Compounds for treatment of artheriosclerosis and hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | claimed |
| EP-0216127-B1 | 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-26 | — | — | EP | claimed |
| EP-0341681-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-15 | — | — | EP | claimed |
| EP-0216127-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | claimed |
| EP-0341681-B1 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| US-5166171-A | Compounds for treatment of artheriosclerosis and hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| US-5166171-A | Compounds for treatment of artheriosclerosis and hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| EP-0244833-B1 | 4(R)-SUBSTITUTED 6(S)-PHENOXYMETHYL-, 6(S)-BETA-PHENYLETHYL- AND 6(S)-BETA-STYRYL-TETRAHYDROPYRAN-2-ONES, A HIGHLY STEREOSELECTIVE PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATION BASED ON THESE COMPOUNDS AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-06-24 | — | — | EP | disclosed |
| EP-0216127-B1 | 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-26 | — | — | EP | disclosed |
| EP-0216127-B1 | 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-26 | — | — | EP | disclosed |
| US-4946852-A | ANTICHOLESTEROL AGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-07 | — | — | US | disclosed |
| EP-0341681-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-15 | — | — | EP | disclosed |
| EP-0244833-A2 | 4(R)-substituted 6(S)-phenoxymethyl-, 6(S)-beta-phenylethyl- and 6(S)-beta-styryl-tetrahydropyran-2-ones, a highly stereoselective process for their preparation, pharmaceutical preparation based on these compounds and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-11-11 | — | — | EP | disclosed |
| EP-0216127-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | disclosed |
| EP-0216127-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | disclosed |
| EP-0216127-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | disclosed |