Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.62 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854003 | 0.76 | PLAU (0.55) | PLAUNOS3NOS1NOS2MAPT | |
| SCHEMBL1851255 | 0.73 | PLAU (0.61) | PLAUNOS3NOS1NOS2MAPT | |
| SCHEMBL292776 | 0.71 | — | — | |
| SCHEMBL2240052 | 0.71 | NOS3 (0.54) | PLAUNOS3NOS1NOS2MAPT | |
| SCHEMBL7663050 | 0.70 | ATM (0.47) | PLAUNOS1PLGCYP2A6MEN1 | |
| SCHEMBL10971356 | 0.70 | — | — | |
| SCHEMBL6404182 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL17893831 | 0.69 | NOS3 (0.52) | PLAUNOS3NOS1NOS2MAPT | |
| SCHEMBL3790728 | 0.68 | SIGMAR1 (0.46) | PLAUMAPTL3MBTL1KDM4ELMNA | |
| SCHEMBL14547704 | 0.68 | PLAU (0.55) | PLAUNOS3NOS1NOS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575490-A1 | GnRH ANALOGS | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1993-12-29 | — | — | EP | disclosed |