Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | F10 | P00742 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513195 | 0.90 | DRD2 (0.69) | KMT2AMEN1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL9513235 | 0.89 | KMT2A (0.67) | KMT2AMEN1F10GAAKDM4E | |
| SCHEMBL31178415 | 0.88 | KMT2A (0.83) | KMT2AMEN1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL9512949 | 0.88 | KMT2A (0.83) | KMT2AMEN1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL25242104 | 0.84 | KMT2A (0.77) | KMT2AMEN1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL31178346 | 0.84 | KMT2A (0.77) | KMT2AMEN1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL9513154 | 0.84 | MEN1 (0.68) | KMT2AMEN1 | |
| SCHEMBL9514579 | 0.83 | ALDH1A1 (0.67) | KMT2AMEN1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL25286763 | 0.82 | KMT2A (0.96) | KMT2AMEN1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL31178374 | 0.82 | KMT2A (0.96) | KMT2AMEN1GAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |
| US-4804661-A | ANALGESICS | CIBA-GEIGY CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |