Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.58 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517058 | 0.98 | RAF1 (0.62) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL19629242 | 0.83 | ADORA1 (0.57) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL9735719 | 0.82 | SOAT1 (0.61) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL9857183 | 0.79 | MAPK13 (0.80) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL19869014 | 0.79 | MAPK14 (1.00) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL6209858 | 0.79 | ADORA1 (0.47) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL6212248 | 0.79 | PI4KA (0.53) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL28845381 | 0.78 | SOAT1 (0.47) | RAF1SOAT1 | |
| SCHEMBL21095336 | 0.78 | ADORA1 (0.52) | RAF1MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL19629249 | 0.78 | ADORA1 (0.52) | RAF1MAPK13MAPK9MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283962-A | Method for synthesizing imidazo [5,1-a ] isoquinoline derivatives through C-H activation/cyclization reaction | 桂林理工大学 | 2023-06-23 | — | — | CN | claimed |
| CN-116283962-A | Method for synthesizing imidazo [5,1-a ] isoquinoline derivatives through C-H activation/cyclization reaction | 桂林理工大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-108395433-A | The method for preparing JAK inhibitor and related intermediate compound | 因西特控股公司 | 2018-08-14 | — | — | CN | disclosed |
| CN-105669676-B | The method for preparing JAK inhibitor and related intermediate compound | 因西特控股公司 | 2018-04-24 | — | — | CN | disclosed |
| CN-105669676-A | Processes for preparing jak inhibitors and related intermediate compounds | 因西特控股公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-105669675-A | Processes for preparing jak inhibitors and related intermediate compounds | 因西特控股公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-102348693-B | Methods for preparing JAK inhibitors and related intermediate compounds | INCYTE CORP. (US) | 2016-03-16 | — | — | CN | disclosed |
| EP-0365907-B1 | Process for the preparation of p-nitrophenyl imidazoles | BASF AG (DE) | 1993-12-22 | — | — | EP | disclosed |
| US-5008398-A | Preparation of p-nitrophenyl-imidazoles | BASF AKTIENGESELLSCHAFT (DE) | 1991-04-16 | — | — | US | disclosed |