Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212248 | 0.87 | PI4KA (0.53) | ADORA1ADORA3RAF1MAPK13MAPK9 | |
| SCHEMBL6210913 | 0.83 | TGFBR1 (0.43) | ADORA1ADORA3RAF1MAPK13MAPK9 | |
| SCHEMBL9514583 | 0.79 | RAF1 (0.64) | ADORA1ADORA3RAF1MAPK13MAPK9 | |
| SCHEMBL9517058 | 0.77 | RAF1 (0.62) | ADORA1ADORA3RAF1MAPK13MAPK9 | |
| SCHEMBL2994696 | 0.72 | PIK3CA (0.65) | — | |
| SCHEMBL4838938 | 0.72 | MAPK14 (0.41) | MAPK13MAPK12MAPK11MAPK14TGFBR1 | |
| SCHEMBL19629249 | 0.68 | ADORA1 (0.52) | ADORA1ADORA3RAF1MAPK13MAPK9 | |
| SCHEMBL19629242 | 0.67 | ADORA1 (0.57) | ADORA1ADORA3RAF1MAPK13MAPK9 | |
| SCHEMBL13217891 | 0.65 | TGFBR1 (0.85) | TGFBR1 | |
| SCHEMBL9857183 | 0.65 | MAPK13 (0.80) | RAF1MAPK13MAPK9MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |