SCHEMBL951470

SCHEMBL951470

O=Cc1cccn1-c1ccccn1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.55
ALDH1A1 P00352 8/20 0.50
GAA P10253 1/20 0.45
KDM4E B2RXH2 2/20 0.43
POLB P06746 2/20 0.42
TRIM24 O15164 1/20 0.41
TRIM33 Q9UPN9 1/20 0.41
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HTT P42858 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PKM P14618 1/20 0.40
CYP1A2 P05177 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
EP300 Q09472 1/20 0.39
KAT2B Q92831 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29728434 1.00 ATM (0.55) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL28817922 0.83 POLB (0.38) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL28616193 0.82 POLB (0.42) ATMALDH1A1KDM4EPOLBTSHR
SCHEMBL19457040 0.81 ALDH1A1 (0.42) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL950165 0.79 ALDH1A1 (0.69) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL28802533 0.77 ALDH1A1 (0.49) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL15181537 0.75 ALDH1A1 (0.50) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL9043362 0.75 ALDH1A1 (0.50) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL28802579 0.72 ATM (0.47) ATMALDH1A1GAAKDM4EPOLB
SCHEMBL951077 0.72 GAA (0.50) ATMALDH1A1GAAKDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114878727-A Method for determining hymexazol residues in tobacco 合肥高尔生命健康科学研究院有限公司 2022-08-09 CN claimed
CN-113321789-B Four polymeric metal complex dye sensitizers containing pyrrole derivatives, and preparation method and application thereof 湘潭大学 2022-05-13 CN claimed
CN-113321789-A Four novel polymeric metal complex dye sensitizers containing pyrrole derivatives, and preparation method and application thereof 湘潭大学 2021-08-31 CN claimed
CN-114878727-B Method for determining hymexazol residues in tobacco 合肥高尔生命健康科学研究院有限公司 2023-07-25 CN disclosed
CN-114878727-A Method for determining hymexazol residues in tobacco 合肥高尔生命健康科学研究院有限公司 2022-08-09 CN disclosed
CN-114773314-A Biarylaminoguanidine derivative 上海拓界生物医药科技有限公司 2022-07-22 CN disclosed
CN-113321789-B Four polymeric metal complex dye sensitizers containing pyrrole derivatives, and preparation method and application thereof 湘潭大学 2022-05-13 CN disclosed
CN-113321789-A Four novel polymeric metal complex dye sensitizers containing pyrrole derivatives, and preparation method and application thereof 湘潭大学 2021-08-31 CN disclosed
US-10813939-B2 Bromodomain inhibitor as adjuvant in cancer immunotherapy H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2020-10-27 US disclosed
US-10676484-B2 Compositions and methods for treating leukemia DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-06-09 US disclosed
US-20200148702-A1 COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS DANA FARBER CANCER INST INC (US) 2020-05-14 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10813939-B2 Bromodomain inhibitor as adjuvant in cancer immunotherapy BRDT, BRD4, BRD1 ATM 444/4885ALDH1A1 2424/4885GAA 3709/4885
US-10676484-B2 Compositions and methods for treating leukemia MCL1, ABL1, FLT3 ATM 887/4885ALDH1A1 1723/4885GAA 1077/4885
US-20200148702-A1 COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS BRPF3, EP300, BRD3 ATM 2001/4885ALDH1A1 3670/4885GAA 2083/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT ATM 4552/4885ALDH1A1 436/4885GAA 1258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.