Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 9/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22946578 | 0.80 | PPARG (0.59) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL27835726 | 0.78 | PPARG (0.48) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3883360 | 0.78 | TBXA2R (0.54) | TBXA2RTBXAS1ESR1 | |
| SCHEMBL14596992 | 0.77 | ALDH1A1 (0.50) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL1115510 | 0.76 | HTR1D (0.47) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3884214 | 0.76 | TBXA2R (0.44) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL13351521 | 0.75 | ALDH1A1 (0.49) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL4259732 | 0.75 | ALDH1A1 (0.49) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL10892857 | 0.74 | TBXA2R (0.74) | TBXA2RTBXAS1PPARA | |
| SCHEMBL10452205 | 0.73 | SMN1; SMN2 (0.49) | TBXA2RTBXAS1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5231106-A | Nervous sytem disorders; blocking og gamma aminobutyric acid | NOVO NORDISK A/S (DK) | 1993-07-27 | — | — | US | disclosed |
| US-5229404-A | Inhibitors of gamma-aminobutyric acid re-uptake, antiepileptic agents | NOVO NORDISK A/S (DK) | 1993-07-20 | — | — | US | disclosed |
| US-5214054-A | Gamma-aminobutyric acid re-uptake inhibitors, antiepileptic, analgesics, anxiolytics | NOVO NORDISK A/S (DK) | 1993-05-25 | — | — | US | disclosed |
| US-5039685-A | Nervous system disorders | NOVO NORDISK A/S (DK) | 1991-08-13 | — | — | US | disclosed |