Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514891 | 0.94 | ARG1 (0.35) | ARG1ARG2CA2ALDH1A1 | |
| SCHEMBL9518761 | 0.94 | ARG1 (0.35) | ARG1ARG2CA2ALDH1A1 | |
| SCHEMBL9514902 | 0.94 | ARG1 (0.35) | ARG1ARG2CA2ALDH1A1 | |
| SCHEMBL9518705 | 0.94 | ARG1 (0.35) | ARG1ARG2CA2ALDH1A1 | |
| SCHEMBL9516132 | 0.94 | ARG1 (0.35) | ARG1ARG2CA2ALDH1A1 | |
| SCHEMBL9516615 | 0.92 | ARG1 (0.34) | ARG1ARG2CA2ALDH1A1 | |
| SCHEMBL9516411 | 0.83 | MME (0.32) | ARG1ARG2 | |
| SCHEMBL9516482 | 0.83 | MME (0.32) | ARG1ARG2 | |
| Ethylenediamine SCHEMBL9515470 | 0.81 | CA2 (0.33) | CA2 | |
| SCHEMBL9518194 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341409-B1 | Platinum (II) complexes, their preparation and use as antitumour agents | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-12-29 | — | — | EP | claimed |