Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513864 | 0.79 | EPHX2 (0.51) | ANPEPEPHX2GAANFKB1NFKB2 | |
| SCHEMBL9515367 | 0.79 | EPHX2 (0.41) | ANPEPEPHX2GAANFKB1NFKB2 | |
| SCHEMBL9515374 | 0.79 | EPHX2 (0.41) | ANPEPEPHX2GAANFKB1NFKB2 | |
| SCHEMBL9515381 | 0.79 | EPHX2 (0.41) | ANPEPEPHX2GAANFKB1NFKB2 | |
| SCHEMBL9515379 | 0.78 | EPHX2 (0.50) | ANPEPEPHX2GAANFKB1NFKB2 | |
| SCHEMBL1718456 | 0.71 | DRD2 (0.48) | ANPEPEPHX2GAANFKB1NFKB2 | |
| SCHEMBL9513876 | 0.69 | ANPEP (1.00) | ANPEP | |
| SCHEMBL10446636 | 0.69 | EPHX2 (0.49) | EPHX2GAANFKB1NFKB2RELA | |
| SCHEMBL26518868 | 0.69 | GAA (0.38) | EPHX2GAANFKB1NFKB2RELA | |
| Isoamylamine SCHEMBL10446310 | 0.69 | EPHX2 (0.44) | EPHX2GAANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378456-B1 | TETRALIN DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5106861-A | Method of using certain tetralin derivatives to produce analgesic relief | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-5041673-A | Aminopeptidase inhibitors, immunomodulators, analgesics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0378456-A1 | Tetralin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-07-18 | — | — | EP | disclosed |