Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM6A | O15550 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM5C | P41229 | 1/20 | 0.49 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.49 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 11/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951999 | 0.89 | APP (0.49) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL12288571 | 0.88 | KDM4E (0.50) | APPHRH3KDM4ETP53CYP2D6 | |
| Hydrochloric Acid SCHEMBL4952642 | 0.88 | APP (0.48) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL10359200 | 0.84 | APP (0.61) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL9513592 | 0.84 | APP (0.61) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL15660704 | 0.84 | KDM4E (0.60) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL15128362 | 0.83 | KDM4E (0.54) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL5136933 | 0.81 | APP (0.58) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL7152347 | 0.81 | APP (0.58) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL15658806 | 0.80 | CHRM2 (0.52) | APPHRH3KDM4ETP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357150-B1 | Pharmaceutical compositions | BRITISH TECH GROUP (GB) | 1993-12-08 | — | — | EP | disclosed |
| US-5104865-A | IRON COMPLEXES OF HYDROXYPYRIDONES USEFUL FOR TREATING IRON OVERLOAD | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1992-04-14 | — | — | US | disclosed |
| EP-0138421-B1 | HYDROXYPYRIDONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-12-05 | — | — | EP | disclosed |
| US-4912118-A | Therapy for toxic concentration of metal | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-03-27 | — | — | US | disclosed |
| EP-0357150-A1 | Pharmaceutical compositions | BTG INTERNATIONAL LIMITED (GB) | 1990-03-07 | — | — | EP | disclosed |
| EP-0138421-A2 | Hydroxypyridone derivatives and pharmaceutical compositions containing them | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1985-04-24 | — | — | EP | disclosed |