SCHEMBL951583

SCHEMBL951583

CN(N)C(=O)c1cc(Cl)cc(Br)c1NC(=O)c1cc(Br)cn1-c1ncccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PSD A5PKW4 1/20 0.35
DHODH Q02127 2/20 0.32
NPSR1 Q6W5P4 2/20 0.32
MALT1 Q9UDY8 5/20 0.32
S1PR1 P21453 1/20 0.32
S1PR3 Q99500 1/20 0.32
RBP4 P02753 1/20 0.31
MAPT P10636 1/20 0.31
PDE4A P27815 1/20 0.31
KCNH2 Q12809 1/20 0.31
TRPV1 Q8NER1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528736 0.94 PSD (0.36) PSDDHODHNPSR1MALT1S1PR1
SCHEMBL951166 0.94 DHODH (0.33) DHODHNPSR1MALT1MAPTTRPV1
SCHEMBL949989 0.92 MALT1 (0.36) PSDDHODHMALT1S1PR1S1PR3
SCHEMBL28944240 0.90 GRM5 (0.33) PSDDHODHMALT1
SCHEMBL12911761 0.90 PSD (0.34) PSDDHODHNPSR1MALT1S1PR1
SCHEMBL12559925 0.88 PSD (0.33) PSDDHODHMALT1RBP4
SCHEMBL12528859 0.87 ALDH1A1 (0.37) DHODHNPSR1MALT1MAPTTRPV1
SCHEMBL12911711 0.86 PSD (0.35) PSDDHODHNPSR1MALT1S1PR1
SCHEMBL12528629 0.86 MALT1 (0.36) PSDDHODHMALT1S1PR1S1PR3
SCHEMBL950391 0.85 DHODH (0.32) DHODHNPSR1MALT1MAPTTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 PSD 4193/4885DHODH 771/4885NPSR1 1050/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT PSD 2662/4885DHODH 284/4885NPSR1 2214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.