Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516876 | 1.00 | TDP1 (0.38) | TDP1L3MBTL1GRK2CASP6CASP8 | |
| SCHEMBL9516869 | 0.89 | TDP1 (0.38) | TDP1ALOX5EPHX2MAPTGAA | |
| SCHEMBL9518151 | 0.86 | GRK2 (0.50) | TDP1L3MBTL1GRK2CASP6CASP8 | |
| SCHEMBL9518140 | 0.86 | GRK2 (0.50) | TDP1L3MBTL1GRK2CASP6CASP8 | |
| SCHEMBL9518146 | 0.86 | GRK2 (0.50) | TDP1L3MBTL1GRK2CASP6CASP8 | |
| SCHEMBL5778978 | 0.70 | ALB (0.58) | TDP1L3MBTL1GRK2CASP6CASP8 | |
| SCHEMBL5777169 | 0.70 | ALB (0.58) | TDP1L3MBTL1GRK2CASP6CASP8 | |
| SCHEMBL9514441 | 0.70 | POLB (0.56) | TDP1L3MBTL1ALOX5EPHX2MAPT | |
| SCHEMBL9515511 | 0.67 | MAPT (0.53) | TDP1L3MBTL1ALOX5EPHX2MAPT | |
| SCHEMBL9515519 | 0.67 | MAPT (0.53) | TDP1L3MBTL1ALOX5EPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219436-B1 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI CHEM IND (JP) | 1993-12-22 | — | — | EP | disclosed |
| US-4902700-A | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1990-02-20 | — | — | US | disclosed |