Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516859 | 0.89 | TDP1 (0.38) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9516876 | 0.89 | TDP1 (0.38) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9518151 | 0.78 | GRK2 (0.50) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9518146 | 0.78 | GRK2 (0.50) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9518140 | 0.78 | GRK2 (0.50) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9516863 | 0.68 | TDP1 (0.47) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9514441 | 0.67 | POLB (0.56) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9516870 | 0.67 | TDP1 (0.49) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9515511 | 0.66 | MAPT (0.53) | TDP1ALOX5EPHX2ALDH1A1KDM4E | |
| SCHEMBL9515519 | 0.66 | MAPT (0.53) | TDP1ALOX5EPHX2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219436-B1 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI CHEM IND (JP) | 1993-12-22 | — | — | EP | disclosed |
| US-4902700-A | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1990-02-20 | — | — | US | disclosed |