Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516863 | 0.84 | TDP1 (0.47) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9514448 | 0.81 | ALOX5 (0.53) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9514441 | 0.73 | POLB (0.56) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9515519 | 0.72 | MAPT (0.53) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9515511 | 0.72 | MAPT (0.53) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9518052 | 0.70 | TOP2A (0.49) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9514857 | 0.70 | TOP2A (0.49) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL10720978 | 0.69 | ALOX5 (0.48) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9514406 | 0.69 | ALOX5 (0.48) | TDP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL9514403 | 0.68 | ALOX5 (0.47) | TDP1MAPTKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219436-B1 | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI CHEM IND (JP) | 1993-12-22 | — | — | EP | disclosed |
| US-4902700-A | Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients | MITSUBISHI KASEI CORPORATION (JP) | 1990-02-20 | — | — | US | disclosed |