Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566760 | 0.90 | RAB9A (0.60) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9515509 | 0.88 | NPC1 (0.50) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9515480 | 0.88 | CXCR2 (0.52) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL9516029 | 0.88 | NPC1 (0.50) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9519528 | 0.84 | RAB9A (0.58) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL3950709 | 0.80 | BAZ2B (0.49) | KMT2AMEN1P4HTMAHRMAPT | |
| SCHEMBL9519589 | 0.78 | CXCR2 (0.54) | KMT2AMEN1P4HTMCXCR1CXCR2 | |
| SCHEMBL9519363 | 0.78 | CXCR1 (0.43) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9515774 | 0.78 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL9519137 | 0.78 | NPC1 (0.54) | NPC1RAB9AKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |