Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CFTR | P13569 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869087 | 0.90 | NLRP3 (0.68) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9141573 | 0.88 | NLRP3 (0.68) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9139795 | 0.88 | NLRP3 (0.68) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL8869981 | 0.88 | NLRP3 (0.67) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9018196 | 0.88 | NLRP3 (0.67) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9516064 | 0.87 | TSHR (0.62) | NLRP3ALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL7871657 | 0.86 | NLRP3 (0.63) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9140218 | 0.85 | NLRP3 (0.64) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9138507 | 0.85 | NLRP3 (0.64) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9516122 | 0.85 | CA1 (0.62) | MEN1ALDH1A1LMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |