Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516122 | 0.94 | CA1 (0.62) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL9516791 | 0.90 | LMNA (0.54) | TSHRALDH1A1MAPTCNR2GAA | |
| SCHEMBL9517098 | 0.90 | ALDH1A1 (0.61) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL8868857 | 0.88 | TSHR (0.61) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL9515766 | 0.88 | KMT2A (0.59) | NPC1RAB9ACA1CA2CA7 | |
| SCHEMBL9517092 | 0.87 | CA1 (0.47) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL9517134 | 0.87 | NLRP3 (0.68) | TSHRALDH1A1MAPTNLRP3CYP3A4 | |
| SCHEMBL8869757 | 0.86 | TSHR (0.60) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL7867669 | 0.85 | TSHR (0.57) | TSHRNPC1RAB9ACA1CA2 | |
| SCHEMBL9138769 | 0.85 | TSHR (0.59) | TSHRNPC1RAB9ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |