Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 8/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518652 | 1.00 | IDH1 (0.40) | IDH1GRM5CYP1A2NR1D1CYP3A4 | |
| SCHEMBL10472217 | 0.88 | MEN1 (0.38) | GRM5CYP1A2NR1D1CYP3A4CACNA1C | |
| SCHEMBL10472218 | 0.88 | MEN1 (0.38) | GRM5CYP1A2NR1D1CYP3A4CACNA1C | |
| SCHEMBL8300387 | 0.79 | IDH1 (0.34) | IDH1 | |
| SCHEMBL8300389 | 0.79 | IDH1 (0.34) | IDH1 | |
| SCHEMBL4420852 | 0.72 | GRM5 (0.55) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL4420849 | 0.72 | GRM5 (0.55) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL4419406 | 0.72 | GRM5 (0.58) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL870748 | 0.70 | ALDH1A1 (0.40) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL16099259 | 0.69 | GRM5 (0.50) | GRM5CYP1A2CYP3A4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330353-B1 | TETRAZOLE EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1993-04-07 | — | — | EP | disclosed |
| US-4968678-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0330353-A1 | Tetrazole excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |