Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CDK13 | Q14004 | 5/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.32 |
| ▸ | CDK7 | P50613 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9342810 | 0.81 | CHRM2 (0.38) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9343630 | 0.79 | NPC1 (0.39) | — | |
| SCHEMBL9342061 | 0.77 | GPR119 (0.36) | GPR119CDK13CDK12CDK7 | |
| SCHEMBL9347112 | 0.75 | CHRM2 (0.34) | CDK13CDK12CDK7CHRM2CHRM4 | |
| SCHEMBL9342139 | 0.72 | CHRM2 (0.38) | GPR119CHRM2CHRM4CHRM5CHRM1 | |
| Fumaric Acid SCHEMBL9343694 | 0.72 | CHRM1 (0.48) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9852852 | 0.67 | CHRM3 (0.55) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL21604582 | 0.61 | ESR2 (0.39) | GPR119 | |
| Oxalic Acid SCHEMBL9342137 | 0.61 | TSHR (0.38) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9724751 | 0.61 | CHRM2 (0.41) | GPR119CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307141-B1 | OXAZOLES AND THIAZOLES FOR THE TREATMENT OF SENILE DEMENTIA | MERCK SHARP & DOHME LTD. (GB) | 1993-01-13 | — | — | EP | disclosed |
| EP-0307141-A2 | Oxazoles and thiazoles for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |