Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 0.41 |
| ▸ | PPARA | Q07869 | 16/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520389 | 1.00 | PPARG (0.41) | PPARGPPARAKDM4EKCNH2FFAR1 | |
| SCHEMBL9520097 | 0.90 | KDM4E (0.45) | PPARGPPARAKDM4EKCNH2PIK3CG | |
| SCHEMBL9520104 | 0.90 | KDM4E (0.45) | PPARGPPARAKDM4EKCNH2PIK3CG | |
| SCHEMBL9521137 | 0.83 | PIM1 (0.49) | PPARGPPARAKDM4E | |
| SCHEMBL9521141 | 0.83 | PIM1 (0.49) | PPARGPPARAKDM4E | |
| SCHEMBL9523273 | 0.82 | KDM4E (0.50) | PPARGPPARAKDM4EFFAR1 | |
| SCHEMBL9379554 | 0.81 | HPGD (0.54) | KDM4E | |
| SCHEMBL9379550 | 0.81 | HPGD (0.54) | KDM4E | |
| SCHEMBL9521885 | 0.81 | PTPN1 (0.43) | PPARGPPARA | |
| SCHEMBL9521889 | 0.81 | PTPN1 (0.43) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1989008651-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |