Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.45 |
| ▸ | DRD3 | P35462 | 10/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9155187 | 1.00 | DRD2 (0.45) | DRD2DRD3HCRTR2KDM4EABCB1 | |
| SCHEMBL9585392 | 0.85 | DRD2 (0.38) | DRD2DRD3HCRTR2KDM4EABCB1 | |
| SCHEMBL9585396 | 0.85 | DRD2 (0.38) | DRD2DRD3HCRTR2KDM4EABCB1 | |
| SCHEMBL9585384 | 0.85 | DRD2 (0.38) | DRD2DRD3HCRTR2KDM4EABCB1 | |
| SCHEMBL2112722 | 0.78 | DRD2 (0.41) | DRD2DRD3HCRTR2LMNA | |
| SCHEMBL2610191 | 0.78 | DRD2 (0.41) | DRD2DRD3HCRTR2LMNA | |
| SCHEMBL2610213 | 0.78 | DRD2 (0.41) | DRD2DRD3HCRTR2LMNA | |
| SCHEMBL34475660 | 0.76 | GRM7 (0.47) | DRD2DRD3HCRTR2 | |
| SCHEMBL8090414 | 0.75 | KDM4E (0.56) | KDM4EABCB1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8090417 | 0.75 | KDM4E (0.56) | KDM4EABCB1ABCC9ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277611-B1 | ALKYL-SUBSTITUTED N-BENZOPYRANYL LACTAMES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS ON THE BASIS OF THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | disclosed |
| EP-0277611-A2 | Alkyl-substituted N-benzopyranyl lactames, process for their preparation, their use and pharmaceutical preparations on the basis of these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-10 | — | — | EP | disclosed |