Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521946 | 0.83 | SIGMAR1 (0.49) | SIGMAR1TAAR1KCNH2AOC3CHRM2 | |
| SCHEMBL9521674 | 0.81 | SIGMAR1 (0.58) | SIGMAR1KCNH2AOC3CHRM2HTR1A | |
| SCHEMBL9523875 | 0.77 | SIGMAR1 (0.49) | SIGMAR1TAAR1KCNH2AOC3CHRM2 | |
| SCHEMBL11813263 | 0.76 | TAAR1 (0.52) | SIGMAR1TAAR1KCNH2AOC3CHRM2 | |
| SCHEMBL9521166 | 0.74 | KCNH2 (0.50) | SIGMAR1KCNH2AOC3CHRM2HTR1A | |
| SCHEMBL9522150 | 0.74 | KDM4E (0.50) | SIGMAR1KCNH2AOC3CHRM2HTR1A | |
| SCHEMBL9520669 | 0.72 | SIGMAR1 (0.51) | SIGMAR1TAAR1 | |
| SCHEMBL9520781 | 0.72 | SIGMAR1 (0.62) | SIGMAR1BCHE | |
| SCHEMBL13569139 | 0.71 | TAAR1 (0.61) | SIGMAR1TAAR1 | |
| SCHEMBL5139428 | 0.71 | TAAR1 (0.61) | SIGMAR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | claimed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | claimed |