Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9520785 | 1.00 | KMT2A (0.50) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| SCHEMBL10484168 | 0.93 | CYP1A2 (0.49) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| Oxalic Acid SCHEMBL9519031 | 0.92 | OPRM1 (0.48) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| Oxalic Acid SCHEMBL9519026 | 0.92 | OPRM1 (0.48) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| Oxalic Acid SCHEMBL9517863 | 0.90 | OPRM1 (0.46) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| Oxalic Acid SCHEMBL9517865 | 0.90 | OPRM1 (0.46) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| SCHEMBL9517273 | 0.85 | CYP1A2 (0.46) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| Cadaverine Tartrate SCHEMBL9518089 | 0.84 | METAP2 (0.47) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| Cadaverine Tartrate SCHEMBL9518091 | 0.84 | METAP2 (0.47) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 | |
| Cadaverine Tartrate SCHEMBL9517398 | 0.83 | METAP2 (0.46) | KMT2AOPRM1OPRD1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | claimed |
| EP-0318234-B1 | IMPROVEMENTS IN OR RELATING TO SELECTIVE SEROTONIN UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0318234-A2 | Improvements in or relating to selective serotonin uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |