Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.53 |
| ▸ | GCGR | P47871 | 3/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846369 | 0.87 | HMGCR (0.53) | HMGCRGCGRDPP4HTR2AHTR2C | |
| SCHEMBL9562922 | 0.87 | HMGCR (0.56) | HMGCRGCGRDPP4HTR2AHTR2C | |
| SCHEMBL9562749 | 0.85 | HMGCR (0.56) | HMGCRGCGRDPP4HTR2AHTR2C | |
| SCHEMBL9562755 | 0.85 | HMGCR (0.56) | HMGCRGCGRDPP4HTR2AHTR2C | |
| SCHEMBL9562801 | 0.84 | HMGCR (0.53) | HMGCRGCGRDPP4HTR2AHTR2C | |
| SCHEMBL10434205 | 0.83 | HMGCR (0.57) | HMGCRGCGRDPP4HTR2AHTR2C | |
| SCHEMBL10433924 | 0.83 | HMGCR (0.57) | HMGCRGCGRDPP4HTR2AHTR2C | |
| SCHEMBL18855250 | 0.81 | GCGR (0.53) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL10433920 | 0.81 | HMGCR (0.53) | HMGCRGCGRDPP4ALDH1A1CYP3A4 | |
| SCHEMBL9562884 | 0.79 | HMGCR (0.54) | HMGCRGCGRDPP4ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302253-B1 | 3-DEMETHYL-4-FLUORO-MEVALONIC-ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS BASED ON THOSE COMPOUNDS, THEIR USE AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-04-07 | — | — | EP | disclosed |
| US-4898868-A | ANTICHOLESTEROL AGENTS; LACTONE OR FREE ACID FORM | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| EP-0302253-A1 | 3-Demethyl-4-fluoro-mevalonic-acid derivatives, process for their preparation, pharmaceutical preparations based on those compounds, their use and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-08 | — | — | EP | disclosed |