Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.55 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.55 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.55 |
| ▸ | COMT | P21964 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522581 | 1.00 | MAPT (0.65) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL10399340 | 0.92 | MAPT (0.58) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL15363575 | 0.90 | CYP19A1 (0.53) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL9522387 | 0.89 | HSP90AA1 (0.53) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL9522391 | 0.89 | HSP90AA1 (0.53) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL9478343 | 0.85 | MAOB (0.73) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL9478353 | 0.85 | MAOB (0.73) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7922516 | 0.83 | CYP1B1 (0.64) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL1405456 | 0.83 | PTGS2 (0.75) | MAPTALDH1A1LMNAKMT2ANPC1 | |
| SCHEMBL6908275 | 0.83 | CYP1B1 (0.64) | MAPTALDH1A1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354583-B1 | DC-88A derivatives | KYOWA HAKKO KOGYO KK (JP) | 1993-11-03 | — | — | EP | disclosed |
| US-5117006-A | DC-88A DERIVATIVES USEFUL AS ANTITUMOR AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| US-5084468-A | Antitumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-28 | — | — | US | disclosed |
| EP-0354583-A1 | DC-88A derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-02-14 | — | — | EP | disclosed |