Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 11/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PTAFR | P25105 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399199 | 0.96 | TBXAS1 (0.56) | TBXAS1TDP1L3MBTL1PTAFRKDM4E | |
| SCHEMBL10399198 | 0.96 | TBXAS1 (0.56) | TBXAS1TDP1L3MBTL1PTAFRKDM4E | |
| SCHEMBL9522362 | 0.86 | TBXAS1 (0.61) | TBXAS1TDP1L3MBTL1PTAFRKDM4E | |
| SCHEMBL27534729 | 0.84 | TBXAS1 (0.62) | TBXAS1TDP1L3MBTL1PTAFRKDM4E | |
| Bicarbonate SCHEMBL9520631 | 0.83 | TBXAS1 (0.64) | TBXAS1TDP1L3MBTL1PTAFRHRH1 | |
| SCHEMBL7319532 | 0.82 | MAPT (0.51) | — | |
| SCHEMBL10398650 | 0.81 | TBXAS1 (0.59) | TBXAS1TDP1L3MBTL1PTAFRKDM4E | |
| SCHEMBL9522427 | 0.81 | TBXAS1 (0.63) | TBXAS1TDP1L3MBTL1PTAFRKDM4E | |
| SCHEMBL10398649 | 0.81 | TBXAS1 (0.59) | TBXAS1TDP1L3MBTL1PTAFRKDM4E | |
| SCHEMBL9520415 | 0.80 | TDP1 (0.59) | TBXAS1TDP1L3MBTL1PTAFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |