Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 3/20 | 0.66 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523187 | 0.81 | ADORA3 (0.56) | FEN1ERCC5ADORA3ADORA2BADORA2A | |
| SCHEMBL10505672 | 0.79 | ADORA2B (0.54) | FEN1ERCC5ADORA3ADORA2BADORA2A | |
| SCHEMBL4217860 | 0.79 | CA12 (0.66) | FEN1ERCC5ADORA3ADORA2BADORA2A | |
| SCHEMBL10507746 | 0.79 | FEN1 (0.66) | FEN1ERCC5ADORA3ADORA2BADORA2A | |
| SCHEMBL6400184 | 0.79 | FEN1 (0.66) | FEN1ERCC5CHEK1KDM4EALDH1A1 | |
| SCHEMBL9523839 | 0.79 | FEN1 (0.66) | FEN1ERCC5ADORA3ADORA2BADORA2A | |
| SCHEMBL18687484 | 0.79 | FEN1 (1.00) | FEN1ERCC5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10507203 | 0.79 | FEN1 (0.60) | FEN1ERCC5ADORA3ADORA2BPGR | |
| SCHEMBL10507086 | 0.78 | ERCC5 (0.59) | FEN1ERCC5ADRA1B | |
| SCHEMBL25237240 | 0.77 | CA12 (0.46) | FEN1ERCC5ADORA3ADORA2BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283162-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-08-11 | — | — | EP | disclosed |
| US-4902686-A | Tricyclic heterocyclic compounds and their use in treating benzodiazepin receptor-related ailments | A/S FERROSAN (DK) | 1990-02-20 | — | — | US | disclosed |
| US-4873244-A | AILMENTS ASSOCIATED WITH BENZODIAZEPINE RECEPTORS | A/S FERROSAN (DK) | 1989-10-10 | — | — | US | disclosed |
| EP-0226282-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | A/S FERROSAN (DK) | 1989-07-05 | — | — | EP | disclosed |
| US-4780539-A | ANTICONVULSANTS, ANXIOLYTIC AGENTS | A/S FERROSAN (DK) | 1988-10-25 | — | — | US | disclosed |
| EP-0283162-A2 | Heterocyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-09-21 | — | — | EP | disclosed |
| US-4771051-A | CENTRAL NERVOUS SYSTEM DISORDERS | A/S FERROSAN (DK) | 1988-09-13 | — | — | US | disclosed |
| EP-0274009-A1 | Oxadiazolylacetonitriles, their preparation and use | NOVO NORDISK A/S (DK) | 1988-07-13 | — | — | EP | disclosed |
| EP-0226282-A2 | Heterocyclic compounds and their preparation and use | A/S FERROSAN (DK) | 1987-06-24 | — | — | EP | disclosed |