Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.40 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776006 | 0.79 | KDM4E (0.62) | EGFRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL18701233 | 0.77 | HSD17B10 (0.45) | EGFRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL18083271 | 0.76 | KDM4E (0.64) | EGFRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL13436033 | 0.75 | SMN1; SMN2 (0.51) | EGFRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL18701121 | 0.75 | SMN1; SMN2 (0.46) | EGFRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL8936671 | 0.72 | EGFR (0.50) | EGFRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL9522612 | 0.71 | KDM4E (0.51) | HSD17B10KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL18083272 | 0.71 | IDO1 (0.52) | HSD17B10KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18083273 | 0.71 | KDM4E (0.51) | EGFRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL18083389 | 0.71 | HSD17B10 (0.62) | HSD17B10KDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129409-B1 | Thiazolo - and thiazinobenzimidazoles | WYETH JOHN & BROTHER LTD (GB) | 1993-10-27 | — | — | EP | disclosed |