Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | TP53 | P04637 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.30 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535632 | 0.88 | MEN1 (0.34) | MAPTMEN1POLBKMT2APIK3CD | |
| SCHEMBL9524294 | 0.86 | ADORA3 (0.34) | MAPTTP53LMNAMEN1POLB | |
| SCHEMBL9522761 | 0.85 | PIK3CD (0.30) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL9522542 | 0.83 | TP53 (0.40) | MAPTTP53LMNAPIK3CDPIK3R2 | |
| SCHEMBL9523576 | 0.83 | TP53 (0.34) | MAPTTP53LMNAMEN1POLB | |
| SCHEMBL9316111 | 0.83 | PIK3CD (0.38) | MAPTTP53LMNAPIK3CDPIK3R2 | |
| SCHEMBL9316680 | 0.83 | MAPT (0.45) | MAPTTP53LMNAPIK3CDPIK3R2 | |
| SCHEMBL9316496 | 0.83 | MEN1 (0.40) | MAPTTP53LMNAMEN1POLB | |
| SCHEMBL9523890 | 0.83 | TP53 (0.35) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL9831280 | 0.83 | PIK3CD (0.37) | MAPTTP53LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |