Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.43 |
| ▸ | PIK3R2 | O00459 | 20/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 20/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 20/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 20/20 | 0.43 |
| ▸ | PIK3R5 | Q8WYR1 | 20/20 | 0.43 |
| ▸ | PIK3R3 | Q92569 | 20/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522313 | 0.90 | PIK3CD (0.53) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9316277 | 0.84 | PIK3CD (0.40) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9523041 | 0.83 | PIK3CD (0.40) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9523571 | 0.81 | PIK3CD (0.54) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9833772 | 0.76 | CYP1A2 (0.36) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9833914 | 0.74 | PTGS1 (0.44) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9832311 | 0.73 | PTGS1 (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9832563 | 0.72 | CCNA2 (0.37) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9834213 | 0.71 | NR1H4 (0.47) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9835879 | 0.71 | ALDH1A1 (0.45) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |