Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 7/20 | 0.61 |
| ▸ | SLC9A1 | P19634 | 7/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14931778 | 0.86 | HCAR3 (0.48) | HCAR3SLC9A1CYP2A6 | |
| SCHEMBL19088929 | 0.86 | HCAR3 (0.45) | HCAR3SLC9A1CYP2A6 | |
| SCHEMBL14931736 | 0.86 | HCAR3 (0.45) | HCAR3SLC9A1CYP2A6 | |
| SCHEMBL28473872 | 0.84 | HCAR3 (0.49) | HCAR3SLC9A1CYP2A6 | |
| SCHEMBL28468120 | 0.82 | HCAR3 (0.46) | HCAR3SLC9A1CYP2A6 | |
| SCHEMBL14942089 | 0.81 | HCAR3 (0.42) | HCAR3SLC9A1CYP2A6PTGER4 | |
| SCHEMBL28470307 | 0.80 | HCAR3 (0.45) | HCAR3SLC9A1 | |
| SCHEMBL15823043 | 0.80 | HCAR3 (0.41) | HCAR3SLC9A1CYP2A6 | |
| SCHEMBL28465267 | 0.80 | HCAR3 (0.46) | HCAR3SLC9A1CYP2A6PTGER4ALDH1A1 | |
| SCHEMBL19848522 | 0.79 | SLC9A1 (0.64) | HCAR3SLC9A1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022184-C | Process for preparing (1 H-imidzol-1-ylmethyl) substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1993-09-22 | — | — | CN | disclosed |
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| CN-88103408-A | Process for preparing (1H-oxazol-1-ylmethyl) substituted benzotriazole derivatives | — | 1988-12-14 | — | — | CN | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |