Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.57 |
| ▸ | PDE2A | O00408 | 2/20 | 0.57 |
| ▸ | PDE6D | O43924 | 2/20 | 0.57 |
| ▸ | PDE8A | O60658 | 2/20 | 0.57 |
| ▸ | PDE5A | O76074 | 2/20 | 0.57 |
| ▸ | PDE9A | O76083 | 2/20 | 0.57 |
| ▸ | PDE8B | O95263 | 2/20 | 0.57 |
| ▸ | PDE6A | P16499 | 2/20 | 0.57 |
| ▸ | PDE6G | P18545 | 2/20 | 0.57 |
| ▸ | PDE6B | P35913 | 2/20 | 0.57 |
| ▸ | PDE6C | P51160 | 2/20 | 0.57 |
| ▸ | PDE1A | P54750 | 2/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.57 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.57 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312042 | 0.84 | DAO (0.58) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL5549672 | 0.80 | PDE2A (0.58) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL7289126 | 0.75 | PDE2A (0.53) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL29579885 | 0.73 | CYP1A2 (0.69) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL982104 | 0.73 | CYP1A2 (0.69) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL7269701 | 0.73 | PDE9A (1.00) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL26671834 | 0.71 | PDE2A (0.51) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL30809703 | 0.70 | PDE2A (0.67) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL7329258 | 0.70 | DAO (0.49) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL31386810 | 0.70 | PDE2A (0.54) | PDE4APDE4BPDE4CPDE4DPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283162-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-08-11 | — | — | EP | disclosed |
| US-4902686-A | Tricyclic heterocyclic compounds and their use in treating benzodiazepin receptor-related ailments | A/S FERROSAN (DK) | 1990-02-20 | — | — | US | disclosed |
| US-4873244-A | AILMENTS ASSOCIATED WITH BENZODIAZEPINE RECEPTORS | A/S FERROSAN (DK) | 1989-10-10 | — | — | US | disclosed |
| EP-0283162-A2 | Heterocyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-09-21 | — | — | EP | disclosed |