Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991183 | 0.77 | HPGD (0.51) | HPGDTSHRL3MBTL1NPC1RAB9A | |
| SCHEMBL3085598 | 0.76 | HSP90AA1 (0.47) | HPGDTSHRL3MBTL1NPC1RAB9A | |
| SCHEMBL9524674 | 0.74 | KMT2A (0.45) | HPGDPOLBMAPTSMN1; SMN2MEN1 | |
| SCHEMBL9523856 | 0.74 | HIF1A (0.55) | HPGDNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL9524896 | 0.74 | HIF1A (0.55) | HPGDNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL9525627 | 0.72 | LCK (0.40) | MEN1KMT2AHTT | |
| SCHEMBL9527969 | 0.72 | RAB9A (0.54) | HPGDNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL9001760 | 0.71 | TSHR (0.79) | HPGDTSHRNPC1RAB9APOLB | |
| SCHEMBL9527463 | 0.70 | LCK (0.38) | TSHRNPC1RAB9APOLBMEN1 | |
| SCHEMBL9523543 | 0.70 | MEN1 (0.44) | HPGDTSHRL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |