Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523856 | 1.00 | HIF1A (0.55) | HIF1ARAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL9527969 | 0.99 | RAB9A (0.54) | HIF1ARAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL9525688 | 0.87 | KAT2B (0.55) | RAB9ANPC1ALDH1A1KMT2AGAA | |
| SCHEMBL9525883 | 0.85 | RAB9A (0.42) | HIF1ARAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL9524789 | 0.78 | RAB9A (0.53) | RAB9AALDH1A1KMT2AGAAEPHX1 | |
| SCHEMBL27990102 | 0.78 | RAB9A (0.46) | HIF1ARAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL27990104 | 0.78 | RAB9A (0.46) | HIF1ARAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL9524962 | 0.74 | CACNA1B (0.51) | RAB9ANPC1 | |
| SCHEMBL9523939 | 0.74 | HPGD (0.48) | RAB9ANPC1ALDH1A1KMT2AHTT | |
| SCHEMBL9525554 | 0.74 | KDM4E (0.54) | ALDH1A1KMT2AMEN1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |