SCHEMBL9524070

SCHEMBL9524070

COC(=O)c1cccc(C(F)F)c1S(=O)(=O)NC(=O)Nc1nccc(OC)n1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.42
NLRP3 Q96P20 1/20 0.36
KMT2A Q03164 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
MEN1 O00255 1/20 0.35
CDK1 P06493 1/20 0.35
SLC40A1 Q9NP59 1/20 0.34
BRAF P15056 1/20 0.34
KDR P35968 1/20 0.34
MAPK14 Q16539 1/20 0.34
TNNI3K Q59H18 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9523882 0.85 GAA (0.42) GAAKMT2ANPC1RAB9AMEN1
SCHEMBL9754529 0.82 GAA (0.53) GAAKMT2ACDK1KDM4EATM
SCHEMBL10455597 0.77 SLC40A1 (0.44) GAAKMT2ANPC1MEN1SLC40A1
SCHEMBL7557766 0.74 GAA (0.55) GAAKMT2AMEN1CDK1
SCHEMBL9754517 0.73 GAA (0.54) GAAKMT2ACDK1
SCHEMBL9522741 0.70 GAA (0.44) GAAKMT2AMEN1CDK1
SCHEMBL9628294 0.70 GAA (0.56) GAAKMT2AMEN1CDK1SLC40A1
SCHEMBL9754346 0.70 GAA (0.46) GAACDK1
SCHEMBL10984018 0.69 GAA (0.60) GAAKMT2ACDK1
SCHEMBL7456581 0.69 GAA (0.49) GAAKMT2ANPC1MEN1CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1991015478-A1 CROP-SELECTIVE HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO claimed
EP-0523067-A1 CROP-SELECTIVE HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-01-20 EP disclosed
WO-1991015478-A1 CROP-SELECTIVE HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO disclosed