Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 3/20 | 0.72 |
| ▸ | HTR1A | P08908 | 2/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.55 |
| ▸ | TUBB | P07437 | 2/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524117 | 1.00 | KRAS (0.72) | KRASHTR1APTGS2ALDH1A1HTT | |
| SCHEMBL760063 | 0.90 | KRAS (0.72) | KRASHTR1APTGS2ALDH1A1HTT | |
| SCHEMBL9523755 | 0.88 | PTGS2 (0.69) | KRASPTGS2ALDH1A1MAPTGAA | |
| SCHEMBL9523759 | 0.88 | PTGS2 (0.69) | KRASPTGS2ALDH1A1MAPTGAA | |
| SCHEMBL1597196 | 0.85 | MAPT (0.66) | PTGS2ALDH1A1HTTMAPTLMNA | |
| SCHEMBL30839393 | 0.85 | MAPT (0.66) | PTGS2ALDH1A1HTTMAPTLMNA | |
| SCHEMBL9522624 | 0.83 | CYP19A1 (0.55) | KRASPTGS2ALDH1A1HTTMAPT | |
| SCHEMBL9522627 | 0.83 | CYP19A1 (0.55) | KRASPTGS2ALDH1A1HTTMAPT | |
| SCHEMBL9478353 | 0.83 | MAOB (0.73) | KRASPTGS2ALDH1A1MAPTLMNA | |
| SCHEMBL9478343 | 0.83 | MAOB (0.73) | KRASPTGS2ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354583-B1 | DC-88A derivatives | KYOWA HAKKO KOGYO KK (JP) | 1993-11-03 | — | — | EP | disclosed |
| US-5117006-A | DC-88A DERIVATIVES USEFUL AS ANTITUMOR AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| US-5084468-A | Antitumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-28 | — | — | US | disclosed |
| EP-0354583-A1 | DC-88A derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-02-14 | — | — | EP | disclosed |