Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 3/20 | 0.38 |
| ▸ | DHFR | P00374 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524143 | 1.00 | GART (0.38) | GARTDHFRALDH1A1MAPK1 | |
| SCHEMBL10568483 | 0.88 | GART (0.41) | GARTDHFR | |
| SCHEMBL9525469 | 0.88 | GART (0.41) | GARTDHFR | |
| SCHEMBL9383820 | 0.86 | DHFR (0.46) | GARTDHFRALDH1A1MAPK1 | |
| SCHEMBL9383825 | 0.86 | DHFR (0.46) | GARTDHFRALDH1A1MAPK1 | |
| SCHEMBL8819377 | 0.85 | GART (0.39) | GARTDHFRALDH1A1 | |
| SCHEMBL8819374 | 0.85 | GART (0.39) | GARTDHFRALDH1A1 | |
| SCHEMBL9381115 | 0.84 | GART (0.31) | GART | |
| SCHEMBL9381108 | 0.84 | GART (0.31) | GART | |
| SCHEMBL9382961 | 0.83 | DHFR (0.47) | GARTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327190-B1 | Pyrido(2,3-d)pyrimidine derivatives | UNIV PRINCETON (US) | 1993-12-08 | — | — | EP | disclosed |
| US-4889859-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-26 | — | — | US | disclosed |