Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 4/20 | 0.41 |
| ▸ | DHFR | P00374 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 3/20 | 0.32 |
| ▸ | FNTB | P49356 | 3/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568483 | 1.00 | GART (0.41) | GARTDHFRKDRROCK2FNTA | |
| SCHEMBL8819377 | 0.91 | GART (0.39) | GARTDHFRROCK2 | |
| SCHEMBL8819374 | 0.91 | GART (0.39) | GARTDHFRROCK2 | |
| SCHEMBL9524143 | 0.88 | GART (0.38) | GARTDHFR | |
| SCHEMBL9524154 | 0.88 | GART (0.38) | GARTDHFR | |
| SCHEMBL8819372 | 0.87 | GART (0.40) | GARTDHFRKDRROCK2MAPK14 | |
| SCHEMBL8819376 | 0.87 | GART (0.40) | GARTDHFRKDRROCK2MAPK14 | |
| SCHEMBL9381356 | 0.86 | GART (0.36) | GARTDHFR | |
| SCHEMBL9381360 | 0.86 | GART (0.36) | GARTDHFR | |
| SCHEMBL9383820 | 0.86 | DHFR (0.46) | GARTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327190-B1 | Pyrido(2,3-d)pyrimidine derivatives | UNIV PRINCETON (US) | 1993-12-08 | — | — | EP | disclosed |
| US-4889859-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0327190-A1 | Pyrido(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-08-09 | — | — | EP | disclosed |