Oxalic Acid

Oxalic Acid

SCHEMBL9524601

Cc1cncn1C(c1ccccc1)c1ccc2nnn(C)c2c1.O=C(O)C(=O)O

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

OPRM1SLC6A4

The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 5/20 0.48
CYP11B1 P15538 3/20 0.46
NOTUM Q6P988 1/20 0.39
MAPK1 P28482 4/20 0.38
ALDH1A1 P00352 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
KEAP1 Q14145 4/20 0.36
SLC9A1 P19634 1/20 0.36
HCAR3 P49019 1/20 0.36
MEN1 O00255 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
GABRA1 P14867 2/20 0.35
GABRB2 P47870 2/20 0.35
CYP11B2 P19099 2/20 0.35
LMNA P02545 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9868394 0.94 CYP19A1 (0.50) CYP19A1CYP11B1NOTUMMAPK1ALDH1A1
SCHEMBL3285588 0.85 CYP19A1 (0.42) CYP19A1CYP11B1MAPK1ALDH1A1TDP1
Oxalic Acid SCHEMBL9525556 0.81 CYP19A1 (0.46) CYP19A1CYP11B1NOTUMMAPK1KEAP1
Oxalic Acid SCHEMBL9523637 0.80 CYP19A1 (0.76) CYP19A1CYP11B1CYP3A4CYP11B2CYP2C19
Oxalic Acid SCHEMBL27267165 0.80 CYP19A1 (0.76) CYP19A1CYP11B1CYP3A4CYP11B2CYP2C19
SCHEMBL2352227 0.73 CYP19A1 (0.58) CYP19A1CYP11B1MAPK1ALDH1A1TDP1
Oxalic Acid SCHEMBL9524290 0.72 CYP19A1 (0.47) CYP19A1CYP11B1MAPK1ALDH1A1TDP1
Oxalic Acid SCHEMBL9524494 0.71 CYP19A1 (0.72) CYP19A1CYP11B1KEAP1RAB9A
SCHEMBL9525014 0.71 KEAP1 (0.50) CYP19A1CYP11B1NOTUMMAPK1KEAP1
Oxalic Acid SCHEMBL9867754 0.70 CYP19A1 (0.46) CYP19A1CYP11B1MAPK1ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0293978-B1 (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1993-09-15 EP disclosed
US-4943574-A AROMATASE INHIBITORS, ESTROGEN DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1990-07-24 US disclosed
EP-0293978-A2 (1H-azol-1-ylmethyl)substituted benzotriazole derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1988-12-07 EP disclosed