Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524664 | 0.88 | KEAP1 (0.52) | KEAP1SLC9A1HCAR3MEN1RAB9A | |
| SCHEMBL9026711 | 0.87 | CYP19A1 (0.58) | KEAP1SLC9A1CYP19A1CYP11B1HCAR3 | |
| SCHEMBL9523778 | 0.84 | POLB (0.53) | CYP19A1KDM4EMAPK1POLBATM | |
| SCHEMBL9527242 | 0.81 | HDAC3 (0.37) | KEAP1MAPK1POLBATMLMNA | |
| Bromide SCHEMBL9523309 | 0.81 | KEAP1 (0.49) | KEAP1SLC9A1CYP19A1CYP11B1HCAR3 | |
| SCHEMBL9524765 | 0.80 | CYP19A1 (0.44) | KEAP1SLC9A1CYP19A1CYP11B1HCAR3 | |
| SCHEMBL9523605 | 0.79 | CYP19A1 (0.43) | KEAP1SLC9A1CYP19A1CYP11B1HCAR3 | |
| SCHEMBL9523595 | 0.79 | LMNA (0.37) | MAPK1POLBATMLMNATSHR | |
| SCHEMBL9523464 | 0.78 | SMN1; SMN2 (0.43) | SLC9A1RAB9AKMT2AKDM4EMAPK1 | |
| SCHEMBL15341829 | 0.77 | CYP19A1 (0.50) | KEAP1SLC9A1CYP19A1CYP11B1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |