Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALB | P02768 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CCKBR | P32239 | 11/20 | 0.57 |
| ▸ | CCKAR | P32238 | 6/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524753 | 1.00 | MEN1 (0.71) | MEN1KMT2ALMNAALBALDH1A1 | |
| SCHEMBL2615325 | 0.83 | LMNA (0.73) | MEN1KMT2ALMNAALBALDH1A1 | |
| Oxazepam SCHEMBL27435 | 0.83 | LMNA (1.00) | MEN1KMT2ALMNAALBCCKBR | |
| Oxazepam SCHEMBL29803925 | 0.83 | LMNA (1.00) | MEN1KMT2ALMNAALBCCKBR | |
| SCHEMBL14160193 | 0.83 | LMNA (0.73) | MEN1KMT2ALMNAALBALDH1A1 | |
| SCHEMBL14213392 | 0.83 | LMNA (0.73) | MEN1KMT2ALMNAALBALDH1A1 | |
| Oxazepam SCHEMBL528376 | 0.83 | LMNA (1.00) | MEN1KMT2ALMNAALBCCKBR | |
| Oxazepam SCHEMBL5498881 | 0.83 | LMNA (1.00) | MEN1KMT2ALMNAALBCCKBR | |
| Oxazepam SCHEMBL9614141 | 0.83 | LMNA (1.00) | MEN1KMT2ALMNAALBCCKBR | |
| Oxazepam SCHEMBL13746806 | 0.83 | LMNA (1.00) | MEN1KMT2ALMNAALBCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273012-B2 | Facile preparation of 4-substituted quinazolines and related heterocycles | UNIVERSITY OF HOUSTON SYSTEM (US) | 2016-03-01 | — | — | US | disclosed |
| US-20120283436-A1 | FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES | THE UNIVERSITY OF HOUSTON (US) | 2012-11-08 | — | — | US | disclosed |
| WO-2012151141-A2 | A FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2012-11-08 | — | — | WO | disclosed |
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5004741-A | Cholecystokinin(CCK); Treating Disorders Of The Gastrointestinal Tract, Central Nervous System And Of The Appetite Of Animals | MERCK & CO., INC. (US) | 1991-04-02 | — | — | US | disclosed |
| US-4820834-A | Benzodiazepine analogs | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0284256-A1 | Benzodiazepine analogs | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4065451-A | CNS DEPRESSANTS | AMERICAN HOME PRODUCTS (US) | 1977-12-27 | — | — | US | disclosed |
| US-4065451-A | CNS DEPRESSANTS | AMERICAN HOME PRODUCTS (US) | 1977-12-27 | — | — | US | disclosed |
| US-3886276-A | 1,3-Dihydro-3 -hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts in compositions and methods for inducing a calming effect | AMERICAN HOME PROD | 1975-05-27 | — | — | US | disclosed |