Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | POLB | P06746 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TNF | P01375 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | POLA1 | P09884 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.52 |
| ▸ | DDX3X | O00571 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527318 | 0.87 | MEN1 (0.53) | KMT2AMEN1POLBMAPTRAB9A | |
| SCHEMBL9523815 | 0.87 | P2RX1 (0.59) | HIF1AKMT2AMEN1POLBMAPT | |
| SCHEMBL9524630 | 0.85 | MEN1 (0.51) | HIF1AKMT2AMEN1POLBMAPT | |
| SCHEMBL9524669 | 0.81 | KMT2A (0.50) | HIF1AKMT2AMEN1POLBMAPT | |
| SCHEMBL9524877 | 0.81 | ADORA3 (0.56) | HIF1AKMT2AMEN1POLBMAPT | |
| SCHEMBL9524794 | 0.81 | ADORA3 (0.48) | HIF1AMAPTDDX3XALDH1A1SMN1; SMN2 | |
| SCHEMBL9523679 | 0.81 | P2RX1 (0.52) | KMT2AMEN1RAB9ALMNANPC1 | |
| SCHEMBL9527182 | 0.81 | NPC1 (0.52) | KMT2AMEN1POLBMAPTRAB9A | |
| SCHEMBL9524321 | 0.81 | FLT3 (0.57) | KMT2AMEN1POLBMAPTRAB9A | |
| SCHEMBL9527500 | 0.81 | ABCG2 (0.51) | KMT2AMEN1POLBMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | claimed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | claimed |
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |