Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524412 | 0.87 | ADORA3 (0.54) | ADORA3KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9527500 | 0.86 | ABCG2 (0.51) | ADORA3KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9527272 | 0.85 | PTPN1 (0.50) | KMT2ANPC1RAB9AMAPTMEN1 | |
| SCHEMBL9524642 | 0.85 | KDM4E (0.45) | KMT2ANPC1RAB9AMAPTMEN1 | |
| SCHEMBL9525587 | 0.85 | ADORA3 (0.47) | ADORA3KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9523845 | 0.84 | LRRK2 (0.50) | ADORA3KMT2ANPC1MAPTMEN1 | |
| SCHEMBL9524293 | 0.82 | TP53 (0.46) | ADORA3KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL9525577 | 0.82 | ADORA3 (0.49) | ADORA3KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9524344 | 0.82 | TMPRSS4 (0.51) | ADORA3KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL9524233 | 0.81 | DHODH (0.54) | ADORA3KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |