Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.49 |
| ▸ | ATR | Q13535 | 4/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524344 | 0.84 | TMPRSS4 (0.51) | ADORA3ELANEPOLBKMT2ANPC1 | |
| SCHEMBL9524293 | 0.84 | TP53 (0.46) | ADORA3ATRELANEPOLBKMT2A | |
| SCHEMBL9525587 | 0.84 | ADORA3 (0.47) | ADORA3ELANEPOLBMAPTKMT2A | |
| SCHEMBL9527446 | 0.84 | ADORA3 (0.51) | ADORA3ATRPOLBMAPTKMT2A | |
| SCHEMBL9524877 | 0.83 | ADORA3 (0.56) | ADORA3ATRELANEPOLBMAPT | |
| SCHEMBL9524794 | 0.83 | ADORA3 (0.48) | ADORA3ELANEMAPTALDH1A1HIF1A | |
| SCHEMBL9523697 | 0.83 | GRM5 (0.52) | ATRKMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL9524874 | 0.82 | ADORA3 (0.50) | ADORA3POLBMAPTKMT2ANPC1 | |
| SCHEMBL9524233 | 0.81 | DHODH (0.54) | ADORA3ELANEPOLBMAPTKMT2A | |
| SCHEMBL9524438 | 0.81 | MEN1 (0.50) | ADORA3KMT2ALMNAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |