Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11473380 | 0.95 | PDE10A (0.51) | TGFBR1PDE10APTGS1PTGS2ALDH1A1 | |
| SCHEMBL7377231 | 0.88 | PDE10A (0.60) | TGFBR1PDE10AATMNPC1RAB9A | |
| SCHEMBL7352490 | 0.88 | PDE10A (0.60) | TGFBR1PDE10AATMNPC1RAB9A | |
| SCHEMBL11485609 | 0.87 | TGFBR1 (0.57) | TGFBR1PDE10AALDH1A1KMT2AMEN1 | |
| SCHEMBL9700092 | 0.85 | PDE10A (0.56) | TGFBR1PDE10AALDH1A1ATMNPC1 | |
| SCHEMBL11474630 | 0.83 | HPGD (0.54) | TGFBR1PDE10AALDH1A1KMT2AMEN1 | |
| SCHEMBL15452608 | 0.82 | TGFBR1 (0.72) | TGFBR1PDE10AALDH1A1KMT2AMEN1 | |
| SCHEMBL9524502 | 0.81 | PDE10A (0.50) | TGFBR1PDE10AALDH1A1KMT2AMEN1 | |
| SCHEMBL9752587 | 0.81 | PDE10A (0.60) | TGFBR1PDE10AALDH1A1KMT2AMEN1 | |
| SCHEMBL14278537 | 0.77 | TGFBR1 (0.52) | TGFBR1PDE10AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561898-A1 | NOVEL PROCESS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-29 | — | — | EP | claimed |
| WO-1992010499-A1 | NOVEL PROCESS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-06-25 | — | — | WO | claimed |