Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.52 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.52 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.52 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121025 | 0.86 | ABCC9 (0.47) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL8311040 | 0.84 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL8123191 | 0.84 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL8796317 | 0.83 | ABCC9 (0.42) | ABCC9ABCC8KCNJ11KCNJ8PSEN1 | |
| SCHEMBL9525790 | 0.83 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8795157 | 0.82 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9527732 | 0.82 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8335425 | 0.81 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL6369348 | 0.79 | ABCC9 (0.62) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL8795283 | 0.79 | ABCC9 (0.38) | ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| CN-1030582-A | 1-benzopyran derivatives | HOFFMANN LA ROCHE (CH) | 1989-01-25 | — | — | CN | disclosed |