Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.49 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700938 | 0.92 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL27267487 | 0.81 | CYP11B1 (0.48) | CYP19A1MAPTCYP11B1CYP11B2 | |
| SCHEMBL10579958 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KMT2ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL2033579 | 0.80 | MAPK1 (0.60) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9662249 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KMT2ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL10581180 | 0.77 | ALDH1A1 (0.61) | ALDH1A1KMT2ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL1924259 | 0.77 | HCAR3 (0.64) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL10580633 | 0.76 | CYP19A1 (0.58) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL14754098 | 0.75 | HCAR3 (0.61) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL10577576 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |