Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | GLA | P06280 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525387 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9526579 | 0.90 | KDM4E (0.56) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9526574 | 0.90 | KDM4E (0.56) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9702640 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9702642 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7371748 | 0.78 | KDM4E (0.57) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL7371751 | 0.78 | KDM4E (0.57) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9701414 | 0.77 | — | — | |
| SCHEMBL9701425 | 0.77 | — | — | |
| SCHEMBL9525815 | 0.76 | KDM4E (0.48) | ALDH1A1KDM4EGLAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550576-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |